What is the difference between AgilePM and PRINCE2?

The difference between AgilePM and PRINCE2, it that AgilePM focuses on managing projects in an Agile environment, whereas PRINCE2 focuses on managing any projects, primarily waterfall projects. Which one of these is most valuable to your and your organisation depends upon the nature of the projects you undertake. If you undertake Agile projects, then choose AgilePM. If you undertake waterfall projects then choose PRINCE2.